Orchid of Eileithyia's Grace
The Orchid of Eileithyia's Grace is an edible flower kept as a prize inside a locked box, and it can only be used by a female.
The Orchid of Eileithyia's Grace looks like a single pink orchid bud, and eating it is an ordeal. The eater falls unconscious for an hour with health down to 1% of the maximum, and no healing is possible until the hour is up. Anyone who survives the hour is granted a permanent boon by the goddess Eileithyia. Which of three boons it is rests with her and cannot be predicted.
The item's own description jokes that the flower might work better as a decoration and probably tastes like a salad from a hippie vegan restaurant. It also calls the whole thing a metaphor for women's weakness and strength.
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